Shen F, Liu YY, Yang JQ, et al. Am J Prev Med. 2026;71(3):108370.
United Kingdom
Meeting 150-300 min/week of moderate-to-vigorous physical activity was associated with lower risks of probable sarcopenia (HR 0.70, 95% CI 0.53-0.91), fractures (0.59, 0.51-0.68), falls (0.53, 0.47-0.61), recurrent fractures (0.60, 0.45-0.81) and recurrent falls (0.53, 0.46-0.62).
Observational cohort; healthy volunteer/UK Biobank selection bias; residual confounding and reverse causation possible; 'probable sarcopenia' rather than full diagnostic phenotype in primary outcome.
UK Biobank adults with 7-day accelerometer-derived physical activity data
Objective UK data reinforce the practical message that guideline-level physical activity is strongly associated with lower future sarcopenia, falls and fracture risk. The magnitude is clinically compelling, but causation cannot be assumed because healthier participants may be more active for reasons not fully captured by adjustment.